UT Southwestern researchers identify brain pathway linked to clozapine weight gain
Source Summary
Researchers at UT Southwestern Medical Center have identified a brain signaling pathway that appears to drive weight gain associated with clozapine, an antipsychotic medication used for treatment-resistant schizophrenia. The preclinical findings, published in Nature Communications, suggest a potential approach to reducing this metabolic side effect.
Why it matters
Clozapine is an important treatment for treatment-resistant schizophrenia, but weight gain limits its use; identifying the underlying mechanism may enable development of strategies to mitigate this side effect.
