Pancreatic cancer cells use clotting pathway to build immune shields, study finds
Source Summary
Researchers at Icahn School of Medicine at Mount Sinai discovered that small populations of pancreatic cancer cells create localized immune-protective niches that shield tumors from immune attack. The finding could enable new approaches to enhance immunotherapy effectiveness against pancreatic cancer, one of the deadliest cancer types.
Why it matters
Understanding how pancreatic tumors evade immune detection could enable development of therapies that overcome this resistance mechanism and improve immunotherapy outcomes for patients with this highly lethal cancer.
