Summit Therapeutics Surges on $2 Billion AstraZeneca Strategic Investment

Source Summary

Summit Therapeutics announced that AstraZeneca will make a $2 billion strategic equity investment in the cancer drugmaker. The two companies will jointly develop drugs as part of the partnership. Summit's shares rose following the announcement.

Why it matters

The $2 billion investment represents a major capital infusion and validation of Summit's cancer drug pipeline by a large pharmaceutical company.

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NASDAQ:SMMTLive chart

Trading trends

The chart totals every SEC-reported transaction by month and share count, separating informative purchases and sales from non-informative awards, vesting, exercises, tax withholding and transfers. Records without a reported price remain included. Only informative purchases and sales affect the conservative sentiment signal.

Recent SEC-reported share and derivative transactions in Summit Therapeutics Inc..

Insider activity sentiment

Neutral

BearishNeutralBullish

0 discretionary purchases · 0 discretionary sales

Confidence: Low

Informative buyNon-informative buyInformative sellNon-informative sell

Insiders	Activity	Description	Shares	Avg. price / share	Est. value	Trade date
Co-Chief Executive OfficerZanganeh Mahkam	Informative buy	Common StockOpen-market or private transaction (P)	3,810,000	$13.12	$49,987,200	Jun 12, 2026
Co-Chief Executive OfficerDUGGAN ROBERT W	Informative buy	Common StockOpen-market or private transaction (P)	3,810,000	$13.12	$49,987,200	Jun 12, 2026
Co-Chief Executive OfficerDUGGAN ROBERT W	Informative buy	Common StockOpen-market or private transaction (P)	100,000	$14.60	$1,460,000	Jun 4, 2026
Co-Chief Executive OfficerZanganeh Mahkam	Informative buy	Common StockOpen-market or private transaction (P)	100,000	$14.60	$1,460,000	Jun 4, 2026
COO and CFOSoni Manmeet Singh	Informative buy	Common StockOpen-market or private transaction (P)	25,000	$14.46	$361,500	Jun 4, 2026

As filed with the SEC. Estimated value is shown only for purchases or sales with a positive reported transaction price; awards, gifts and similar activity are not assigned an assumed market value. Amendments may change the record. This is not investment advice.

Short interest

Open short positions reported twice monthly; this is not daily short-sale volume.

Earnings

Recent reported earnings per share compared with the analyst consensus available from Nasdaq.

Comments

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Owner	Activity	Change	Shares held	Value (thousands)	Reported
Baker Bros. Advisors Lp	Sell	-3,604,715 (-9.905%)	32,786,348	$511,795	6/30/2026
Vanguard Group Inc	Sell	-202,508 (-1.78%)	11,177,220	$174,476	12/31/2025
Fmr Llc	Sell	-809,252 (-7.456%)	10,043,947	$156,786	6/30/2026
State Street Corp	Buy	2,508,636 (35.694%)	9,536,796	$148,869	6/30/2026
Blackrock, Inc.	Sell	-124,717 (-1.292%)	9,529,041	$148,748	6/30/2026
Vanguard Capital Management Llc	Buy	22,682 (0.397%)	5,734,484	$89,515	6/30/2026
Ubs Group Ag	Buy	1,553,483 (42.211%)	5,233,798	$81,700	6/30/2026
Vanguard Portfolio Management Llc	Sell	-191,062 (-3.651%)	5,042,190	$78,709	6/30/2026
Goldman Sachs Group Inc	Buy	4,202,671 (1352.524%)	4,513,399	$70,454	6/30/2026
Price T Rowe Associates Inc /Md/	Sell	-4,384,039 (-52.961%)	3,893,820	$60,783	6/30/2026
Point72 Asset Management, L.P.	Buy	2,913,617 (371.547%)	3,697,803	$57,723	6/30/2026
Geode Capital Management, Llc	Buy	111,409 (3.36%)	3,427,263	$53,500	6/30/2026

Settlement date	Short interest	Avg. daily volume	Change vs. previous report	Days to cover
Sep 15, 2026	41,081,179	6,260,891	-0.60%	6.56
Aug 31, 2026	41,330,352	6,240,461	+10.41%	6.62
Aug 14, 2026	37,432,330	4,308,749	+3.27%	8.69
Jul 31, 2026	36,245,370	4,091,058	-2.90%	8.86
Jul 15, 2026	37,327,940	3,386,533	-6.34%	11.02
Jun 30, 2026	39,855,640	5,958,124	+8.27%	6.69
Jun 15, 2026	36,811,691	8,254,320	+1.90%	4.46
May 29, 2026	36,126,988	4,410,564	—	8.19

Fiscal quarter	Reported	EPS	Consensus	Surprise
Jun 2026	Jul 23, 2026	-0.28	-0.26	-7.69%
Mar 2026	Apr 30, 2026	-0.24	-0.33	+27.27%
Dec 2025	Feb 23, 2026	-0.29	-0.22	-31.82%
Sep 2025	Oct 20, 2025	-0.31	-0.14	-121.43%

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